Effects of Parathyroid Hormone on Immune Function
نویسندگان
چکیده
منابع مشابه
Effects of Parathyroid Hormone on Immune Function
Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis. Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells). The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to method...
متن کاملEffects of acute and chronic hypercalcemia on parathyroid function and circulating parathyroid hormone molecular forms.
Bas et al. (1), in this issue, have demonstrated that acute hypercalcemic clamp over 2 h in rabbits reduces the subsequent intact (I) parathyroid hormone (PTH) response to hypocalcemia by 50%, while chronic hypercalcemia, secondary to experimental renal failure in the same animal model, fails to reduce the I-PTH response to hypocalcemia. These results raise questions about the acute and chronic...
متن کاملEffects of Parathyroid Hormone on Osteoblast Differentiation
It has been reported that PTH exerts bone-forming effects in vivo when administered intermittently. In the present study, the anabolic effects of PTH(1-34) on osteoblast differentiation were examined in vitro. Osteoblastic cells isolated from newborn rat calvaria were cyclically treated with PTH(1-34) for the first few hours of each 48-h incubation cycle. When osteoblastic cells were intermitte...
متن کاملThe Effects of Parathyroid Hormone and Thyrocalcitonin
A B S T R A C r Labeled proline from incubation media has been shown to be incorporated into living bone matrix collagen in vitro. Hydroxyproline is released from fresh bone slices in similar systems in a characteristic curve against time. This hydroxyproline is derived from three distinct sources, each of which may be separately quantitated. Part of the total represents passive solubilization ...
متن کاملThe effects of age and gender on parathyroid hormone dynamics.
BACKGROUND AND AIMS Hyperparathyroidism is a risk factor for bone loss. An age-related increase in parathyroid hormone (PTH) level has been demonstrated in several studies. It has been suggested that the type II osteoporotic syndrome, a condition of increased prevalence among elderly women, may be at least partially caused by elevations in intact parathyroid hormone (iPTH) levels. To date, howe...
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ژورنال
عنوان ژورنال: Clinical and Developmental Immunology
سال: 2010
ISSN: 1740-2522,1740-2530
DOI: 10.1155/2010/418695